The problem of import substitution is connected with the task of accelerated development and production of new products and technology. Basic directions of the organization of import substituting production: flexible adaptive fabrication, the correspondence of the methods of production organization to the requirements of a engineering-technological base, management efficiency, provision with workers and specialists in the field of manufacturing and management; a fulfillment of personnel policy directed to constant training and motivation of personnel; an adequate integrated automated system of production management directed to the solution of import substitution problems. The creation of administrative-economic conditions ensuring efficiency increase in enterprise functioning on the basis of the application of efficient production principles is substantiated. The approach to the choice of the index system in the assessment of production-economic activity manifesting engineering and economic peculiarities of import substitution production is described. The tasks on the organization of production under conditions of import substitution are formed. The regulations defining a purposefulness of production process automation are substantiated. The approach to the integration and optimization of production and management is developed. Basic elements of a stan-dard integrated automated system for the management of engineering plants are described.